If you have heavy memory charge with driver locked it means that it is used by kernel-mode drivers. The goal is to transfer data for a certain period.
It is normal if it doesn’t last long. Otherwise something is fishy.
Maybe a virtual machine is taking too much memory. You have to determine which one and to stop it.
It can be an hardware issue.
It can be due to a mode of your memory that would be enabled, like Dynamic Memory.