Windows Server 2008 RAM memory almost full

If you have heavy memory charge with driver locked it means that it is used by kernel-mode drivers. The goal is to transfer data for a certain period.

It is normal if it doesn’t last long. Otherwise something is fishy.

Maybe a virtual machine is taking too much memory. You have to determine which one and to stop it.

It can be an hardware issue.

It can be due to a mode of your memory that would be enabled, like Dynamic Memory.