How to draw comics with a mouse in Photoshop ?
With a graphic tablet, you can draw fast and smooth lines, while with a mouse it becomes quickly complicated. Too pixelated.
The main solution consists in drawing with a higher resolution and a larger brush. You will select the third rounded brush at the top.
Then you will resize the picture once finished.
Here is an example of what we can get with a mouse :
Here the brush was too tick. So do some tests before to make a full page of comics. Also you will have to add some effect like tick lines at certain location of the picture to make it more like a real drawing.